Familiar themes in a new instance of scientific misconduct: the Kuklo case.

The New York Times has an article about a physician-scientist caught in scientific misconduct. The particular physician-scientist, Dr. Timothy R. Kuklo, was an Army surgeon working at Walter Reed Army Medical Center. He is now (for the time being anyway) a professor of medicine at Washington University in St. Louis. Since the wrongdoing of which Kuklo was accused happened while he was at Walter Reed, the Army investigated.
That investigation “substantiated all the accusations against the physician.”
The Kuklo case has lots of ethical issues we’ve seen before. The New York Times article goes through them for the Nth time. That we’ve seen these same issues in misconduct and “misbehavior” cases on many, many, occasions might make one wonder how scientists, journal editors, and corporate sponsors of research failed to internalize any of the lessons they might have learned from the (N-1) times that came before this one.
After all, they’re supposed to be good at spotting trends in the data.
Among the familiar themes in this case, I notice:

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The mechanics of getting fooled: the multiple failures in the fraud of Jan Hendrik Schön.

There’s an interesting article in the Telegraph by Eugenie Samuel Reich looking back at the curious case of Jan Hendrik Schön. In the late ’90s and early ’00s, the Bell Labs physicist was producing a string of impressive discoveries — most of which, it turns out, were fabrications. Reich (who has published a book about Schön, Plastic Fantastic: How the Biggest Fraud in Physics Shook the Scientific World) considers how Schön’s frauds fooled his fellow physicists. Her recounting of the Schön saga suggests clues that should have triggered more careful scrutiny, if not alarm bells.
Of Schön’s early work at Bell Labs, Reich writes:

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Mentoring ethics and authorship ethics.

One of my correspondents told me about a situation that raised some interesting questions about both proper attribution of authorship in scientific papers and ethical interactions between mentor and mentee in a scientific training relationship. With my correspondent’s permission, I’m sharing the case with you.
A graduate student, in chatting with a colleague in another lab, happened upon an idea for an experimental side project to do with that colleague. While the side project fell well outside the research agenda of this graduate student’s research group, he first asked his advisor whether it was OK for him to work on the side project. The advisor was reluctant to allow the student to work on the project, but agreed to give him a relatively short window of time (on the order of weeks, not months) to work on the side project and see if he got any results.

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A serious contender for dumbest excuse of 2008.

He defended the views he expressed in many of his radio programs and said that, because he consulted for so many drugmakers at once, he had no particular bias.
“These companies compete with each other and cancel each other out,” he said.

The New York Times on psychiatrist and former radio host, Dr. Frederick K. Goodwin, whose NPR program “The Infinite Mind” was cancelled after it was discovered that Goodwin failed to disclose more than $1 million in income received for giving marketing lectures for drugmakers.
Dr. Goodwin seems a little unclear on the concept of conflict of interest.

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Conditions for ethical therapeutic use of a placebo.

Jake has a great post up today about the frequency with which American internists and rheumatologists prescribe placebos and the ethical questions this raises. Jake writes:

For my part, I don’t think I would be comfortable deceiving my patient under any circumstances. I see my role as a future physician partly as a healer but also as an educator. Patients — particularly patients with intractable chronic illnesses — want to understand what is happening to them. I almost feel like in deceiving them, I would be denying them that small measure of control — that small measure of dignity — that is vital to feeling like a complete person, even in the face of a life destroying illness. The ability to make decisions for yourself is an empowering feeling. You only take that away if you are absolutely convinced — as in the case of dementia or severe mental illness — that someone is completely incapable.

The whole post is well worth reading. But I’m wondering whether there couldn’t be some conditions under which use of a placebo wouldn’t violate a patient’s dignity.

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The kind of thing that makes industry ‘science’ look bad.

In a post last week, I mentioned a set of standards put forward by Carol Henry (a consultant and former vice president for industry performance programs at the American Chemistry Council), who says they would improve the credibility of industry-funded research.
But why does industry-funded research have a credibility problem in the first place? Aren’t industry scientists (or academic scientists whose research is supported by money from industry) first and foremost scientists, committed to the project of building accurate and reliable knowledge about the world? As scientists, aren’t they just as hard-headed and devoted to objectivity — indeed, to truth — as the rest of their professional community?
I have no doubt that many industry (and industry-funded) scientists do take good knowledge-building as their most important job. And this means that some of those who depart from this commitment are making things harder for those scientists whose loyalties to their industry benefactors do not extend to misrepresenting the truth. Plus, of course, they may be misleading policy makers and the public by passing off as reliable scientific knowledge something that is not.
In the article “Tobacco Industry Influence on Science and Scientists in Germany,” [1] Thilo Grüning, Anna B. Gilmore, and Martin McKee draw on internal tobacco industry documents (released in 1998 as part of the settlement of litigation by the state of Minnesota against tobacco companies) to identify the strategies tobacco companies used to influence scientists and to distort science.

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Standards for industry-funded research.

In the August 25, 2008 issue of Chemical & Engineering News, there’s an interview with Carol Henry (behind a paywall). Henry is a consultant who used to be vice president for industry performance programs at the American Chemistry Council (ACC). In the course of the interview, Henry laid out a set of standards for doing research that she thinks all scientists should adopt. (Indeed, these are the standards that guided Henry in managing research programs for the California Environmental Protection Agency, the U.S. Department of Energy, the American Petroleum Institute, and ACC.)
Here are Carol Henry’s research standards:

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Aetogate aftermath: paleontologists discuss the norms of their discipline.

Finally, here is the long awaited fourth part in my three part series examining the Society for Vertebrate Paleontology Ethics Education Committee response to the allegations of scientific misconduct against Spencer Lucas and co-workers. Part 3 was a detailed examination of the “best practices” document (PDF) issued by this committee. In this post, I make a brief foray into the conversations paleontologists have been having online about their understanding of the accepted practices in their field.
As these conversations are ongoing (and some of them are happening on listservs to which I do not subscribe), what I present here is just a snapshot of how some members of the professional community of paleontologists (and those in related fields) describe the working rules of their professional activities and interactions. What’s striking to me, though, is that these scientists are responding to the Aetogate controversy by having these conversations.

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Considering an ethicist’s ‘questionable behavior’.

The press covering the story of bioethicist Glenn McGee’s departure from the post of director of the Alden March Bioethics Institute at Albany Medical College is hungry for an ironic twist. For example, Scientific American titles its article “An Unethical Ethicist?” What more fitting fall than some self-appointed morality cop going down on account of his own immoral dealings?
Believe me, I’m familiar with the suspicions people seem to harbor that ethicists are, in fact, twice as naughty as other folks. But from the evidence laboriously assembled in the SciAm article, I’m just not buying the picture of McGee laughing maniacally while twirling his mustache and plotting all manner of evil. (To be fair, despite the headline, I don’t think the SciAm piece is arguing that McGee is a villain, either.) Rather, I’m inclined to think that he made a few bad calls, but that the most likely explanation for his departure is good old fashioned academic politics.

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