The Hellinga Retractions (part 1): when replication fails, what should happen next?

Because Abi asked me to, I’m going to discuss the fascinating case of the Hellinga retractions. Since this is another case where there is a lot to talk about, I’m going to take it in two parts. In the first part, working from the Chemical & Engineering News article by Celia Henry Arnaud (May 5, 2008) [1], I’ll focus on the common scientific activity of trying to build on a piece of published work. What happens when the real results seem not to fit with the published results? What should happen?

In part 2, drawing from the Nature news feature by Erika Check Hayden (May 15, 2008) [2], I’ll consider this case in the context of scientific collaborations — both within research groups and between research groups. In light of the differentials in experience and power (especially between graduate students and principal investigators), who is making the crucial scientific decisions, and on the basis of what information?
But let’s start with the papers [3,4] that came out of the research group of Homme W. Hellinga, professor of biochemistry at Duke University.

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Relationships in lab groups.

This post is standing in for a lecture and class discussion that would be happening today if I knew how to be in two places at once. (Welcome Phil. 133 students! Make yourselves at home in the comments, and feel free to use a pseudonym if you’d rather not comment under your real name.)

The topic at hand is the way relationships in research groups influence the kind of science that comes out of those groups, as well as the understanding the members of the group have of what it means to do good science. Our jumping off point is an article by Vivian Weil and Robert Arzbaecher titled “Relationships In Laboratories and Research Communities.” [1]

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Do jokes reveal something about who you’re talking to?

On April Fool’s Day, our local Socrates CafĂ© had an interesting discussion around the question of what makes something funny. One observation that came up repeatedly was that most jokes seem aimed at particular audiences — at people who share particular assumptions, experiences, and contexts with the person telling the joke. The expectation is that those “in the know” will recognize what’s funny, and that those who don’t see the humor are failing to find the funny because they’re not in possession of the crucial knowledge or insight held by those in the in-group. Moreover, the person telling the joke seems effectively to assert his or her membership in that in-group. People in the discussion probed the question of whether there was anything that could be counted on to be universally funny; our tentative answer was, “Probably not.”
With this hunch about joking in hand, I wanted to take a closer look at a particular joke and what it might convey.

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A dialogue on pseudonymity, personae, and interpersonal relations in the blogosphere.

Janet D. Stemwedel: Hey, can we talk about pseudonymous blogging?

Dr. Free-Ride: Haven’t you already written a bunch of posts about that?

Janet D. Stemwedel: Yeah, but the blogosphere seems to be discussing it again.

Dr. Free-Ride: You know I only work on Fridays, right?

Janet D. Stemwedel: Get your pseudonymous butt in gear and help me have a proper dialogue!

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Honesty, diplomacy, independence, and solidarity in public discussions about science.

At DrugMonkey, PhysioProf explores the rules of engagement between grad students in journal club and seminar presentations (building off of interesting explorations of this question from A Lady Scientist, Dr. Jekyll & Mrs. Hyde, and Acmegirl — all of which you should click through to read in their entirety). I’m late to the party, but I wanted to share some thoughts on the balance here between the intellectual aspects and the human aspects of questioning within the tribe of science.

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Trying to understand framing (III): the example of stem cell research.

I haven’t given up yet. You know I’m still looking for more clarity on the basic premises of framing. I tried to work out what does and does not fall within the framing strategy in a flowcharted example and (again) came away with a bunch of unanswered questions.
This round, I’m going to look at an example from the Nisbet and Scheufele article in The Scientist (a link to the PDF given here. I’ll confess that I’m still confused, but I think I’m getting closer to identifying precisely what I’m confused about.
Here’s what Nisbet and Scheufele say in The Scientist article about communication about stem cell research:

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Trying to understand framing (II): draw me a picture.

You’ll remember that I tried to work out precisely what was being claimed in the premises behind framing set out by Chris Mooney. At the end of this exercise, I was left with the hunch that one’s optimal communication strategy — and how much scientific detail it will require — might depend an awful lot on what kind of message you’re trying to get across to your audience, to the point where trying to generalize about framing doesn’t seem very helpful. At least, it’s not helpful to me as I’m still trying to understand the strategy.
So, I’m hopeful that those who are hip to the framing thing can help me work through a less general example, presented on the hand-drawn flowchart below:

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